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Executive summary  Biotech is a broad-scoped discipline. As biomedicine has the   In order to foster the above-mentioned ecosystem, it is incumbent
                                                                            for the two cities to devise a comprehensive, concrete and long-
                 highest significance and the biggest potential for collaboration, it
                 forms the focus of the present study. Having taken into account
                                                                            term plan. We make four recommendations (Recommendations
                                                                            1–4) for the reference of the two governments to address existing
                 the respective strengths and development directions of the two
                                                                            barriers that hamper collaboration. Moreover, the development of
                 cities, four major areas of collaboration centred on the Loop are
                                                                            biotech in Hong Kong and Shenzhen is closely related to national
                 put forward (Table 1):
                                                                            planning and policies. The Central Government’s support is
                                                                            essential for addressing issues of a more marco or cross-border
                 Table 1    Four major areas of collaboration between       nature. We thus put forward three recommendations
                          Hong Kong and Shenzhen
                                                                            (Recommendations 5–7) for the reference of Central Ministries
                   Area of           Overview of mode of collaboration      and Departments.
                   collaboration
                                     Coordinated in the Loop to achieve all-  Recommendation 1    Establishing anchor
                   Drugs and         stage and multifactored collaboration that   institutions in the region to expedite development
                   vaccines          encompasses drug development,            of a biotech industrial cluster
                                     production and product launch
                                                                            Hong Kong and Shenzhen have yet to establish a world-renowned
                                     With collaborative development in the
                                     Loop, teams in Hong Kong and Shenzhen   biotechnology industrial cluster. Meanwhile, Shanghai and Boston
                   Genetic testing   will focus on different markets; market   have adopted an “anchor institution” approach: major enterprises
                   and therapies     access restrictions will be eased to allow   or research institutes were introduced to create an environment
                                     eligible enterprises in the Loop to enter the   conducive to the development of local start-ups and industries.
                                     Mainland market                        This in turn facilitates the formation of a world-class biotech
                   Advanced medical   Corporates establish themselves in the   industrial cluster.
                   devices           Loop to leverage Hong Kong’s strengths in
                                     medical research and clinical trials and   Drawing on the above-mentioned approach, we recommend that
                   Application of AI to   Shenzhen’s expertise in AI and mechanical   a multipronged strategy be adopted to expedite the development
                   biotechnology     manufacturing                          of the HK-SZ biotech industrial cluster in the Loop. In the short-
                                                                            term, government departments and relevant organisations in the
                                                                            two cities should proactively approach leading biotech enterprises.
                                                                            Incentives like tax concessions, rental discounts and government-
                                                                            guaranteed low-interest loans can be provided to attract

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